Computational analysis of the sequence-structure relation in SARS-CoV-2 spike protein using protein contact networks

Abstract The structure of proteins impacts directly on the function they perform. Mutations in the primary sequence can provoke structural changes with consequent modification of functional properties. SARS-CoV-2 proteins have been extensively studied during the pandemic. This wide dataset, related...

Full description

Bibliographic Details
Main Authors: Pietro Hiram Guzzi, Luisa di Paola, Barbara Puccio, Ugo Lomoio, Alessandro Giuliani, Pierangelo Veltri
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30052-w