Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs

Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs

New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds <b>6b</b> and <b>6j</b> showed higher in vitro COX-2 selectivity and inhibitory activity (IC<sub>50</sub> = 0.0...

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Bibliographic Details
Main Authors: Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Daabees, Ahmed E. Abdel Moneim, Mostafa M. M. El-Miligy
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
sulfonamides
1,2,3-triazole
NSAIDs
in vivo anti-inflammatory
COX-2 inhibitors
Online Access:https://www.mdpi.com/1424-8247/15/10/1165

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https://www.mdpi.com/1424-8247/15/10/1165

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