Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice

Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice

Summary: Auxilin (DNAJC6/PARK19), an endocytic co-chaperone, is essential for maintaining homeostasis in the readily releasable pool (RRP) by aiding clathrin-mediated uncoating of synaptic vesicles. Its loss-of-function mutations, observed in familial Parkinson’s disease (PD), lead to basal ganglia...

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Bibliographic Details
Main Authors: Xi Cheng, Yu Tang, D.J. Vidyadhara, Ben-Zheng Li, Michael Zimmerman, Alexandr Pak, Sanghamitra Nareddula, Paige Alyssa Edens, Sreeganga S. Chandra, Alexander A. Chubykin
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Physiology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223019193

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223019193

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