High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis.

High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis.

There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin has therapeutic benefit despite microbiological resistance remains uncle...

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Bibliographic Details
Main Authors: Elize Pietersen, Jonny Peter, Elizabeth Streicher, Frik Sirgel, Neesha Rockwood, Barbara Mastrapa, Julian Te Riele, Malika Davids, Paul van Helden, Robin Warren, Keertan Dheda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4409172?pdf=render

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http://europepmc.org/articles/PMC4409172?pdf=render

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