Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptionally silences either the maternal or paternal X in e...

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Bibliographic Details
Main Authors: Amy L Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S El-Sayed Moustafa, Max Tomlinson, Ruth CE Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J Steves, Massimo Mangino, Jordana T Bell, Chloe CY Wong, Timothy J Vyse, Kerrin S Small
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
haematopoiesis
cardiovascular disease
cancer
X chromosome inactivation
Online Access:https://elifesciences.org/articles/78263

Internet

https://elifesciences.org/articles/78263

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