Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin
Keypoints Taxonomically distant species have a wide diversity of roseocin family lantibiotics. The phylogeny-guided approach opens new possibilities for RiPPs bioengineering. Bioactive variants of roseocin were generated using semi-in vitro reconstitution.
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2023-03-01
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Series: | AMB Express |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13568-023-01536-9 |