Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Keypoints Taxonomically distant species have a wide diversity of roseocin family lantibiotics. The phylogeny-guided approach opens new possibilities for RiPPs bioengineering. Bioactive variants of roseocin were generated using semi-in vitro reconstitution.

Bibliographic Details
Main Authors: Sandeep Chaudhary, Shweta Kishen, Mangal Singh, Sunanda Jassal, Reeva Pathania, Kalpana Bisht, Dipti Sareen
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:AMB Express
Subjects:
Actinobacteria
Lantibiotics
Phylum
Post-translational modification
Variants
Online Access:https://doi.org/10.1186/s13568-023-01536-9

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