Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections

Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections

Repetitive implant-related infections (IRIs) are devastating complications in orthopedic surgery, threatening implant survival and even the life of the host. Biofilms conceal bacterial-associated antigens (BAAs) and result in a ''cold tumor''-like immune silent microenvironment,...

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Bibliographic Details
Main Authors: Dongdong Xu, Jun Hu, Jiawei Mei, Jun Zhou, Zhengxi Wang, Xudong Zhang, Quan Liu, Zheng Su, Wanbo Zhu, Hongjian Liu, Chen Zhu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-05-01
Series:Bioactive Materials
Subjects:
Implant-related infections
Systemic immunotherapy
cGAS-STING pathway
Interferon
Neutrophil activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000306

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http://www.sciencedirect.com/science/article/pii/S2452199X24000306

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