Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans

Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans

Abstract Background Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting selective signatures in the Tibetan genomes. Results Here, we present whole-g...

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Bibliographic Details
Main Authors: Wangshan Zheng, Yaoxi He, Yongbo Guo, Tian Yue, Hui Zhang, Jun Li, Bin Zhou, Xuerui Zeng, Liya Li, Bin Wang, Jingxin Cao, Li Chen, Chunxia Li, Hongyan Li, Chaoying Cui, Caijuan Bai, Baimakangzhuo, Xuebin Qi, Ouzhuluobu, Bing Su
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
Tibetan
High-altitude adaptation
Whole-genome sequencing
1KTGP
Cardio-pulmonary functions
Positive selection
Online Access:https://doi.org/10.1186/s13059-023-02912-1

Internet

https://doi.org/10.1186/s13059-023-02912-1

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