Histone malonylation is regulated by SIRT5 and KAT2A

Summary: The posttranslational modification lysine malonylation is found in many proteins, including histones. However, it remains unclear whether histone malonylation is regulated or functionally relevant. Here, we report that availability of malonyl-co-enzyme A (malonyl-CoA), an endogenous malonyl...

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Những tác giả chính: Ran Zhang, Joanna Bons, Grace Scheidemantle, Xiaojing Liu, Olga Bielska, Chris Carrico, Jacob Rose, Indra Heckenbach, Morten Scheibye-Knudsen, Birgit Schilling, Eric Verdin
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Elsevier 2023-03-01
Loạt:iScience
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Truy cập trực tuyến:http://www.sciencedirect.com/science/article/pii/S2589004223002705