Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine
2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methy...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2013-11-01
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Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.9.292 |