Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methy...

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Bibliographic Details
Main Authors: Ashley R. Longstreet, Suzanne M. Opalka, Brian S. Campbell, B. Frank Gupton, D. Tyler McQuade
Format: Article
Language:English
Published: Beilstein-Institut 2013-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
continuous
flow chemistry
HIV
Knoevenagel
nevirapine
nicotinonitriles
Online Access:https://doi.org/10.3762/bjoc.9.292

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