Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures?
Purpose Electroencephalography (EEG) is useful for clarifying the association between cortical activity and cognitive processes in children. We investigated whether EEG abnormalities were correlated with developmental delay/intellectual disability (DD/ID) in the absence of clinical seizures. Methods...
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| Format: | Article |
| Language: | English |
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Korean Child Neurology Society
2024-04-01
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| Series: | Annals of Child Neurology |
| Subjects: | |
| Online Access: | http://annchildneurol.org/upload/pdf/acn-2024-00444.pdf |
| _version_ | 1827287427721461760 |
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| author | Yoo Jung Lee Yoon Hee Jo Soo Han Choi Hye Won Yoo Ha Young Jo Su Jeong Park Kyung Hee Park Ju Hyun Kong Yun Jin Lee Sang Ook Nam Young Mi Kim |
| author_facet | Yoo Jung Lee Yoon Hee Jo Soo Han Choi Hye Won Yoo Ha Young Jo Su Jeong Park Kyung Hee Park Ju Hyun Kong Yun Jin Lee Sang Ook Nam Young Mi Kim |
| author_sort | Yoo Jung Lee |
| collection | DOAJ |
| description | Purpose Electroencephalography (EEG) is useful for clarifying the association between cortical activity and cognitive processes in children. We investigated whether EEG abnormalities were correlated with developmental delay/intellectual disability (DD/ID) in the absence of clinical seizures. Methods We retrospectively identified 166 children with DD/ID who underwent EEG at Pusan National University Hospital between January 2011 and December 2021. We compared clinical characteristics and test results between those with normal and those with abnormal EEGs. Additionally, we analyzed EEG abnormalities in relation to neurodevelopmental disorders, specifically autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Results Of the 166 patients, 39 (23.5%) displayed abnormal EEGs, while 127 (76.5%) had normal EEGs. Of the former, 25 (64.1%) patients exhibited epileptiform discharges, including 22 (56.3%) with focal and three (7.7%) with generalized discharges. Focal discharges most frequently affected the central area (35.9%). Twenty patients (51.3%) exhibited rhythmic slowing patterns. Epilepsy diagnoses were significantly more common among patients with abnormal EEGs (n=8, 20.5%) than among those with normal EEGs (n=9, 7.1%) (P<0.001). Of 22 patients with ASD, five (12.8%) had abnormal EEGs. Of 13 patients with ADHD, five (36.4%) had abnormal EEGs, all with epileptiform discharges. Two patients with ASD and two with ADHD exhibited rhythmic slowing. Abnormal EEG findings were significantly more common among those with genetic abnormalities compared to genetically normal patients (26 vs. 13, P=0.017). Conclusion EEG represents a potential screening tool for children with DD. Abnormal EEG findings are associated with increased epilepsy risk, informing diagnosis and treatment planning. |
| first_indexed | 2024-04-24T10:59:18Z |
| format | Article |
| id | doaj.art-1642571cf5624d9e8c4f1148a3325310 |
| institution | Directory Open Access Journal |
| issn | 2635-909X 2635-9103 |
| language | English |
| last_indexed | 2024-04-24T10:59:18Z |
| publishDate | 2024-04-01 |
| publisher | Korean Child Neurology Society |
| record_format | Article |
| series | Annals of Child Neurology |
| spelling | doaj.art-1642571cf5624d9e8c4f1148a33253102024-04-12T01:51:06ZengKorean Child Neurology SocietyAnnals of Child Neurology2635-909X2635-91032024-04-0132210511410.26815/acn.2024.004441357Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures?Yoo Jung Lee0Yoon Hee Jo1Soo Han Choi2Hye Won Yoo3Ha Young Jo4Su Jeong Park5Kyung Hee Park6Ju Hyun Kong7Yun Jin Lee8Sang Ook Nam9Young Mi Kim10 Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Korea Department of Pediatrics, Pusan National University Children’s Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Yangsan, Korea Department of Pediatrics, Pusan National University Children’s Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Yangsan, Korea Department of Pediatrics, Pusan National University Children’s Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Yangsan, Korea Department of Pediatrics, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine, Busan, KoreaPurpose Electroencephalography (EEG) is useful for clarifying the association between cortical activity and cognitive processes in children. We investigated whether EEG abnormalities were correlated with developmental delay/intellectual disability (DD/ID) in the absence of clinical seizures. Methods We retrospectively identified 166 children with DD/ID who underwent EEG at Pusan National University Hospital between January 2011 and December 2021. We compared clinical characteristics and test results between those with normal and those with abnormal EEGs. Additionally, we analyzed EEG abnormalities in relation to neurodevelopmental disorders, specifically autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Results Of the 166 patients, 39 (23.5%) displayed abnormal EEGs, while 127 (76.5%) had normal EEGs. Of the former, 25 (64.1%) patients exhibited epileptiform discharges, including 22 (56.3%) with focal and three (7.7%) with generalized discharges. Focal discharges most frequently affected the central area (35.9%). Twenty patients (51.3%) exhibited rhythmic slowing patterns. Epilepsy diagnoses were significantly more common among patients with abnormal EEGs (n=8, 20.5%) than among those with normal EEGs (n=9, 7.1%) (P<0.001). Of 22 patients with ASD, five (12.8%) had abnormal EEGs. Of 13 patients with ADHD, five (36.4%) had abnormal EEGs, all with epileptiform discharges. Two patients with ASD and two with ADHD exhibited rhythmic slowing. Abnormal EEG findings were significantly more common among those with genetic abnormalities compared to genetically normal patients (26 vs. 13, P=0.017). Conclusion EEG represents a potential screening tool for children with DD. Abnormal EEG findings are associated with increased epilepsy risk, informing diagnosis and treatment planning.http://annchildneurol.org/upload/pdf/acn-2024-00444.pdfelectroencephalographydevelopmental disabilitiesintellectual disabilityepilepsygenetic testing |
| spellingShingle | Yoo Jung Lee Yoon Hee Jo Soo Han Choi Hye Won Yoo Ha Young Jo Su Jeong Park Kyung Hee Park Ju Hyun Kong Yun Jin Lee Sang Ook Nam Young Mi Kim Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? Annals of Child Neurology electroencephalography developmental disabilities intellectual disability epilepsy genetic testing |
| title | Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? |
| title_full | Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? |
| title_fullStr | Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? |
| title_full_unstemmed | Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? |
| title_short | Is Electroencephalography Useful in Children with Developmental Delays but without Overt Seizures? |
| title_sort | is electroencephalography useful in children with developmental delays but without overt seizures |
| topic | electroencephalography developmental disabilities intellectual disability epilepsy genetic testing |
| url | http://annchildneurol.org/upload/pdf/acn-2024-00444.pdf |
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