Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation

Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation

Cis-diamminedichloroplatinum (II) (CDDP) is a widely used antineoplastic agent with numerous associated side effects. We investigated the mechanisms of action of the indole derivative N’-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide...

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Bibliographic Details
Main Authors: Tayyaba Afsar, Suhail Razak, Janeen H. Trembley, Khushbukhat Khan, Maria Shabbir, Ali Almajwal, Nawaf W. Alruwaili, Muhammad Umar Ijaz
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
cisplatin
indole
testicular tissues
molecular interactome
molecular docking
antineoplastic agent
Online Access:https://www.mdpi.com/2076-3921/11/10/2063

Internet

https://www.mdpi.com/2076-3921/11/10/2063

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