Maternal stress induced endoplasmic reticulum stress and impaired pancreatic islets’ insulin secretion via glucocorticoid receptor upregulation in adult male rat offspring

Maternal stress induced endoplasmic reticulum stress and impaired pancreatic islets’ insulin secretion via glucocorticoid receptor upregulation in adult male rat offspring

Abstract Exposure to perinatal (prenatal and/or postnatal) stress is considered as a risk factor for metabolic disorders in later life. Accordingly, this study aimed to investigate the perinatal stress effects on the pancreatic endoplasmic reticulum (ER) stress induction, insulin secretion impairmen...

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Bibliographic Details
Main Authors: Mina Salimi, Farzaneh Eskandari, Fateme Binayi, Afsaneh Eliassi, Hossein Ghanbarian, Mehdi Hedayati, Javad Fahanik-babaei, Mohamad Eftekhary, ‬Rana Keyhanmanesh, Homeira Zardooz
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16621-5

Internet

https://doi.org/10.1038/s41598-022-16621-5

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