Interleukin-27 impairs BCG antigen clearance and T cell stimulatory potential by neonatal dendritic cells

Bacille Calmette Guérin (BCG) is a live-attenuated vaccine for protection against Mycobacterium tuberculosis. Despite high disease protection in infancy and early childhood, it generates poor long-term protection against pulmonary tuberculosis. We hypothesized that the unique immune profile that inc...

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Bibliographic Details
Main Authors: Shelby D. Bradford, Michelle R. Witt, Jessica M. Povroznik, Cory M. Robinson
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Microbial Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517422000736