Sparse conserved under-methylated CpGs are associated with high-order chromatin structure

Sparse conserved under-methylated CpGs are associated with high-order chromatin structure

Abstract Background Whole-genome bisulfite sequencing (WGBS) is the gold standard for studying landscape DNA methylation. Current computational methods for WGBS are mainly designed for gene regulatory regions with multiple under-methylated CpGs (UMCs), such as promoters and enhancers. Results To rel...

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Bibliographic Details
Main Authors: Xueqiu Lin, Jianzhong Su, Kaifu Chen, Benjamin Rodriguez, Wei Li
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Biology
Subjects:
Sparse conserved under-methylated CpG
Whole-genome bisulfite sequencing
Multi-sample-based method
Chromatin-loop factors
Interacting anchor
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s13059-017-1296-x

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http://link.springer.com/article/10.1186/s13059-017-1296-x

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