Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

Mitochondrial ATP production in ventricular cardiomyocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca2+ ([Ca2+]m) and blood flow that is tuned by local cardiomyocyte metabol...

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Bibliographic Details
Main Authors: Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A Mannella, W Jonathan Lederer, Liron Boyman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
mitochondrial ATP production
heart
ventricular myocytes
cAMP
soluble adenylyl cyclase
calcium
Online Access:https://elifesciences.org/articles/84204

Internet

https://elifesciences.org/articles/84204

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