Protease-activated receptor-2 regulates trypsin expression in the brain and protects against seizures and epileptogenesis

Protease-activated receptor-2 (PAR2), primarily involved in inflammation, is highly expressed in limbic regions of the brain such as the hippocampus. Although extracellular proteolysis is involved in normal and stress-related neuronal plasticity associated with learning, memory and inflammatory dise...

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Bibliographic Details
Main Authors: Rink-Jan Lohman, Terence J. O'Brien, Thomas M. Cocks
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002732