Sinapic acid alleviates 5-fluorouracil-induced nephrotoxicity in rats via Nrf2/HO-1 signalling

Sinapic acid alleviates 5-fluorouracil-induced nephrotoxicity in rats via Nrf2/HO-1 signalling

Fluoropyrimidine 5-fluorouracil (5-FU) is a DNA analogue broadly used in chemotherapy, though treatment-associated nephrotoxicity limits its widespread clinical use. Sinapic acid (SA) has potent antioxidant, anti-inflammatory, and anti-apoptotic effects, we investigated its protective effects agains...

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Bibliographic Details
Main Authors: Mushtaq Ahmad Ansari, Mudassar Shahid, Sheikh F. Ahmad, Ajaz Ahmad, Abdulrazaq Alanazi, Abdul Malik, Yousef A. Bin Jardan, Sabry M. Attia, Saleh A. Bakheet, Mohammad Raish
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Pharmaceutical Journal
Subjects:
5-FU
Sinapic acid
Nephrotoxicity
Oxidative stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423001470

Internet

http://www.sciencedirect.com/science/article/pii/S1319016423001470

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