Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Abstract Background This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS...

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Bibliographic Details
Main Authors: Jianmei Yang, Enli Wang, Mingmin Jiang, Yujun Tan, Fangfang Yao, Chenghong Sun, Lihong Pan, Ling Gao, Jingchun Yao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Ovarian Research
Subjects:
Orlistat
Obesity
Polycystic ovary syndrome
Gut microbiota
Metabolomics
Online Access:https://doi.org/10.1186/s13048-023-01193-3

Internet

https://doi.org/10.1186/s13048-023-01193-3

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