Free Cholesterol Affects the Function and Localization of Human Na<sup>+</sup>/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)

Free Cholesterol Affects the Function and Localization of Human Na<sup>+</sup>/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane. We assessed the impact of adding or removing free chole...

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Bibliographic Details
Main Authors: Jessica Y. Idowu, Bruno Hagenbuch
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
NTCP
OCT1
transporter
lipid raft
cholesterol
methyl-β-cyclodextrin
Online Access:https://www.mdpi.com/1422-0067/23/15/8457

Internet

https://www.mdpi.com/1422-0067/23/15/8457

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