New 4-Aminoproline-Based Small Molecule Cyclopeptidomimetics as Potential Modulators of α<sub>4</sub>β<sub>1</sub> Integrin

New 4-Aminoproline-Based Small Molecule Cyclopeptidomimetics as Potential Modulators of α<sub>4</sub>β<sub>1</sub> Integrin

Integrin α<sub>4</sub>β<sub>1</sub> belongs to the leukocyte integrin family and represents a therapeutic target of relevant interest given its primary role in mediating inflammation, autoimmune pathologies and cancer-related diseases. The focus of the present work is the des...

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Bibliographic Details
Main Authors: Andrea Sartori, Kelly Bugatti, Elisabetta Portioli, Monica Baiula, Irene Casamassima, Agostino Bruno, Francesca Bianchini, Claudio Curti, Franca Zanardi, Lucia Battistini
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
aminoproline scaffold
integrin targeting
ligand design
peptidomimetic synthesis
leukocyte integrins
Online Access:https://www.mdpi.com/1420-3049/26/19/6066

Internet

https://www.mdpi.com/1420-3049/26/19/6066

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