Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model

Interferon gamma (IFNg) is a pleiotropic cytokine that can potentially reprogram the tumor microenvironment; however, the antitumor immunomodulatory properties of IFNg still need to be validated due to variable therapeutic outcomes in preclinical and clinical studies. We developed a replication-defi...

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Bibliographic Details
Main Authors: Olga Trofimova, Ksenija Korotkaja, Dace Skrastina, Juris Jansons, Karina Spunde, Maria Isaguliants, Anna Zajakina
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Vaccines
Subjects:
interferon gamma
cancer immunotherapy
viral vectors
alphavirus
bone-marrow-derived macrophages
spheroids
Online Access:https://www.mdpi.com/2076-393X/9/11/1247

Internet

https://www.mdpi.com/2076-393X/9/11/1247

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