Pharmacokinetic-pharmacodynamic correlation of imipenem in pediatric burn patients using a bioanalytical liquid chromatographic method

Pharmacokinetic-pharmacodynamic correlation of imipenem in pediatric burn patients using a bioanalytical liquid chromatographic method

<p>A bioanalytical method was developed and applied to quantify the free imipenem concentrations for pharmacokinetics and PK/PD correlation studies of the dose adjustments required to maintain antimicrobial effectiveness in pediatric burn patients. A reverse-phase Supelcosil LC18 column (250 x...

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Bibliographic Details
Main Authors: Silvia Regina Cavani Jorge Santos, Cristina Sanches-Giraud, Carlindo Vieira Silva Júnior, David Souza Gomez
Format: Article
Language:English
Published: Universidade de São Paulo 2015-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Imipenem/quantificação
Antibióticos/dosagem
Pacientes pediátricos/queimaduras/uso de antibióticos
Cromatografia líquida de alta eficiência/análise quantitativa
Monitoramento plasmático
PK/PD
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200305&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200305&lng=en&tlng=en

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