The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function.

The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function.

Human genetic and animal studies have implicated the costimulatory molecule CD40 in the development of multiple sclerosis (MS). We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832. Previo...

Full description

Bibliographic Details
Main Authors: Judith Field, Fernando Shahijanian, Stephen Schibeci, Australia and New Zealand MS Genetics Consortium (ANZgene), Laura Johnson, Melissa Gresle, Louise Laverick, Grant Parnell, Graeme Stewart, Fiona McKay, Trevor Kilpatrick, Helmut Butzkueven, David Booth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4465929?pdf=render

Internet

http://europepmc.org/articles/PMC4465929?pdf=render

Similar Items