Differential Regulation of Echinocandin Targets Fks1 and Fks2 in <em>Candida glabrata </em>by the Post-Transcriptional Regulator Ssd1

Differential Regulation of Echinocandin Targets Fks1 and Fks2 in <em>Candida glabrata </em>by the Post-Transcriptional Regulator Ssd1

Invasive infections caused by the opportunistic pathogen <i>Candida glabrata</i> are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of genes (<i>FKS1</i...

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Bibliographic Details
Main Authors: Kelley R. Healey, Padmaja Paderu, Xin Hou, Cristina Jimenez Ortigosa, Nicole Bagley, Biren Patel, Yanan Zhao, David S. Perlin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Journal of Fungi
Subjects:
<i>Candida glabrata</i>
echinocandin resistance
FKS mutation
FKS regulation
SSD1
Online Access:https://www.mdpi.com/2309-608X/6/3/143

Internet

https://www.mdpi.com/2309-608X/6/3/143

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