CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues

Summary: Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7bKO) have decreased BAT mass and impaired β3-adrenergic signaling and...

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Bibliographic Details
Main Authors: Honglei Ji, Yizhe Chen, Judit Castillo-Armengol, René Dreos, Catherine Moret, Guy Niederhäuser, Brigitte Delacuisine, Isabel C. Lopez-Mejia, Pierre-Damien Denechaud, Lluis Fajas
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Biological Sciences
Endocrinology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303485

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220303485

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