Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics

Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics

It has long been understood that some proteins undergo conformational transitions en route to the Michaelis Complex to allow chemistry. Examination of crystal structures of glycosyltransferase enzymes in the GT-B structural class reveals that the presence of ligand in the active site triggers an ope...

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Bibliographic Details
Main Authors: Carlos A. Ramirez-Mondragon, Megin E. Nguyen, Jozafina Milicaj, Bakar A. Hassan, Frank J. Tucci, Ramaiah Muthyala, Jiali Gao, Erika A. Taylor, Yuk Y. Sham
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
GT
glycosyltransferase
HepI
heptosyltransferase I
heptose
L-<i>glycero</i>-<span style="font-variant: small-caps">d</span>-<i>manno</i>-heptose
Online Access:https://www.mdpi.com/1422-0067/22/9/4619

Internet

https://www.mdpi.com/1422-0067/22/9/4619

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