Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastati...

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Bibliographic Details
Main Authors: Ved P. Sharma, Binwu Tang, Yarong Wang, Camille L. Duran, George S. Karagiannis, Emily A. Xue, David Entenberg, Lucia Borriello, Anouchka Coste, Robert J. Eddy, Gina Kim, Xianjun Ye, Joan G. Jones, Eli Grunblatt, Nathan Agi, Sweta Roy, Gargi Bandyopadhyaya, Esther Adler, Chinmay R. Surve, Dominic Esposito, Sumanta Goswami, Jeffrey E. Segall, Wenjun Guo, John S. Condeelis, Lalage M. Wakefield, Maja H. Oktay
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27308-2

Internet

https://doi.org/10.1038/s41467-021-27308-2

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