Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations

The acetophenone-based 3,4-dihydropyrimidine-2(1H)-thione was synthesized by the reaction of 4-methylpent-3-en-2-one (<b>1</b>), 4-acetyl aniline (<b>2</b>) and potassium thiocyanate. The spectroscopic analysis including: FTIR, <sup>1</sup>H-NMR, and single crysta...

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Bibliographic Details
Main Authors: Aamer Saeed, Syeda Abida Ejaz, Aqsa Khalid, Pervaiz Ali Channar, Mubashir Aziz, Qamar Abbas, Tanveer A. Wani, Nawaf A. Alsaif, Mohammed M. Alanazi, Abdullah M. Al-Hossaini, Nojood Altwaijry, Seema Zargar, Muawya Elhadi, Tuncer Hökelek
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
thione
dihydropyrimidine
single crystal analysis
DFT
molecular docking
Online Access:https://www.mdpi.com/1422-0067/23/21/13164

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https://www.mdpi.com/1422-0067/23/21/13164

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