Cocrystallization of Gefitinib Potentiate Single-Dose Oral Administration for Lung Tumor Eradication via Unbalancing the DNA Damage/Repair

Cocrystallization of Gefitinib Potentiate Single-Dose Oral Administration for Lung Tumor Eradication via Unbalancing the DNA Damage/Repair

Gefitinib (GEF) is a clinical medication for the treatment of lung cancer targeting the epidermal growth factor receptor (EGFR). However, its efficacy is remarkably limited by low solubility and dissolution rates. In this study, two cocrystals of GEF with co-formers were successfully synthesized usi...

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Bibliographic Details
Main Authors: Muhammad Inam, Yi Yang, Jialin Hu, Jiena Zheng, Wenxia Deng, You Zhou, Jialong Qi, Chuanshan Xu, Guihong Chai, Yuanye Dang, Wenjie Chen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceutics
Subjects:
co-formers
gefitinib
cocrystal
DNA damage and repair
oral administration
Online Access:https://www.mdpi.com/1999-4923/15/12/2713

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https://www.mdpi.com/1999-4923/15/12/2713

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