Total saponins of Bolbostemma paniculatum (maxim.) Franquet exert antitumor activity against MDA-MB-231 human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway

Total saponins of Bolbostemma paniculatum (maxim.) Franquet exert antitumor activity against MDA-MB-231 human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway

Abstract Background The aim of the present study was to examine the effects of the Bolbostemma paniculatum (Maxim.) Franquet (BP) active compound, BP total saponins (BPTS), on MDA-MB-231 cells, and investigate the underlying mechanism regarding BPTS-mediated attenuation of the PI3K/Akt/mTOR pathway....

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Bibliographic Details
Main Authors: Jian-Wei Dou, Rong-Guo Shang, Xiao-Qin Lei, Kang-Le Li, Zhan-Zi Guo, Kai Ye, Xiao-Juan Yang, Yu-Wei Li, Yun-Yun Zhou, Jia Yao, Qian Huang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Bolbostemma paniculatum (maxim.) Franquet
Total saponins
MDA-MB-231 cells
PI3K/Akt/mTOR, signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12906-019-2708-0

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http://link.springer.com/article/10.1186/s12906-019-2708-0

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