Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia

Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia

Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;21)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells, we investigated...

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Bibliographic Details
Main Authors: Sai Huang, Meng-Meng Jiang, Guo-Feng Chen, Kun Qian, Hong-Hao Gao, Wei Guan, Jin-Long Shi, An-Qi Liu, Jing Liu, Bian-Hong Wang, Yong-Hui Li, Li Yu
Format: Article
Language:English
Published: Wolters Kluwer 2016-01-01
Series:Chinese Medical Journal
Subjects:
Acute Myeloid Gene 1-Eight-twenty-one; Acute Myeloid Leukemia; Epigenetics; Eyes Absent 4
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=11;spage=1355;epage=1362;aulast=Huang

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http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=11;spage=1355;epage=1362;aulast=Huang

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