Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in the blood and is associated with a reduced immunogenicity. As antigen presentation is a primary event in the activation of CD4 T-cells and initiation of Anti-Drug Antibody (ADA) response, we investigated the...

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Bibliographic Details
Main Authors: Marie de Bourayne, Sylvain Meunier, Samuel Bitoun, Evelyne Correia, Xavier Mariette, Hervé Nozach, Bernard Maillère
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
certolizumab pegol
immunogenicity
PEGylation
CD4 T-cell response
T-cell epitope
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.808606/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.808606/full

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