Performance of 16S Metagenomic Profiling in Formalin-Fixed Paraffin-Embedded versus Fresh-Frozen Colorectal Cancer Tissues

Performance of 16S Metagenomic Profiling in Formalin-Fixed Paraffin-Embedded versus Fresh-Frozen Colorectal Cancer Tissues

Formalin-fixed, paraffin-embedded (FFPE) tissues represent the most widely available clinical material to study colorectal cancer (CRC). However, the accuracy and clinical validity of FFPE microbiome profiling in CRC is uncertain. Here, we compared the microbial composition of 10 paired fresh-frozen...

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Bibliographic Details
Main Authors: Alessandra Borgognone, Garazi Serna, Marc Noguera-Julian, Lidia Alonso, Mariona Parera, Francesc Català-Moll, Lidia Sanchez, Roberta Fasani, Roger Paredes, Paolo Nuciforo
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
microbiome
colorectal cancer
16S gene sequencing
RNA in situ hybridization
FFPE
Online Access:https://www.mdpi.com/2072-6694/13/21/5421

Internet

https://www.mdpi.com/2072-6694/13/21/5421

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