Metabolism and in vitro assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene

Metabolism and in vitro assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene

Objectives 1-Methylnaphthalene (1-MN) is composed of 2 benzene rings and belongs to polycyclic aromatic hydrocarbons. The metabolism of 1-MN in laboratory animals and bacteria leads to the formation of 1-naphthoic acid (1-NA). Material and Methods In this study the distribution of 1-NA in lung, liv...

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Bibliographic Details
Main Authors: Radosław Świercz, Maciej Stępnik, Jolanta Gromadzińska, Katarzyna Domeradzka-Gajda, Joanna Roszak, Wojciech Wąsowicz
Format: Article
Language:English
Published: Nofer Institute of Occupational Medicine 2022-09-01
Series:International Journal of Occupational Medicine and Environmental Health
Subjects:
rats
inhalation
micronucleus test
toxicokinetics
1-methylonaphthalene
1-naphthoic acid
Online Access:http://ijomeh.eu/Metabolism-and-in-vitro-assessment-of-the-mutagenic-activity-of-urinary-extracts,151556,0,2.html

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http://ijomeh.eu/Metabolism-and-in-vitro-assessment-of-the-mutagenic-activity-of-urinary-extracts,151556,0,2.html

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