Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

Following previous studies on anthraquinone and acridine-based G-quadruplex ligands, here we present a study of similar aromatic cores, with the specific aim of increasing G-quadruplex binding and selectivity with respect to duplex DNA. Synthesized compounds include two and three-side chain xanthone...

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Bibliographic Details
Main Authors: Alessandro Altieri, Antonello Alvino, Stephan Ohnmacht, Giancarlo Ortaggi, Stephen Neidle, Daniele Nocioni, Marco Franceschin, Armandodoriano Bianco
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
G-quadruplex
xanthene
xanthone
ESI-MS
FRET
telomere
c-myc
bcl-2
Online Access:http://www.mdpi.com/1420-3049/18/11/13446

Internet

http://www.mdpi.com/1420-3049/18/11/13446

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