Development of 18F-Labeled Resazurin Derivatives for the Detection of Tumor Metabolic Activity Using Cerenkov Imaging

Development of 18F-Labeled Resazurin Derivatives for the Detection of Tumor Metabolic Activity Using Cerenkov Imaging

This paper describes functional fluorinated bioactivatable molecules to study cancer metabolism using Cerenkov imaging. Resazurin (RA), or Alamar Blue, is a commonly used viability dye and redox sensor. Under reductive conditions or by the action of NADH dehydrogenases, RA is reduced into resorufin...

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Bibliographic Details
Main Authors: Alejandro D. Arroyo, Andrea E. Guzman, Alexander V. Kachur, Anatoliy V. Popov, E. James Delikatny
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physics
Subjects:
cerenkov imaging
cancer metabolism
in vivo imaging
activatable probes
cerenkov radiation energy transfer
Online Access:https://www.frontiersin.org/articles/10.3389/fphy.2021.652179/full

Internet

https://www.frontiersin.org/articles/10.3389/fphy.2021.652179/full

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