Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell

Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell

A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggestive cause of failure in adaptive beta-cell expansio...

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Bibliographic Details
Main Authors: Chutima Chanprasert, Nutchanawan Promnakhon, Nontaphat Thongsin, Siriwal Suwanpitak, Nattachet Plengvidhya, Pa-thai Yenchitsommanus, Prapaporn Jungtrakoon Thamtarana, Methichit Wattanapanitch
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Stem Cell Research
Subjects:
Familial diabetes of the adulthood
Autosomal dominant diabetes
ZYG11A
iPSC
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122000642

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http://www.sciencedirect.com/science/article/pii/S1873506122000642

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