E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

E3 ubiquitin ligase Cbl-b plays a crucial role in T cell activation and tolerance induction. However, the molecular mechanism by which Cbl-b inhibits T cell activation remains unclear. Here, we report that Cbl-b does not inhibit PI3K but rather suppresses TCR/CD28-induced inactivation of Pten. The e...

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Bibliographic Details
Main Authors: Hui Guo, Guilin Qiao, Haiyan Ying, Zhenping Li, Yixia Zhao, Yanran Liang, Lifen Yang, Stanley Lipkowitz, Josef M. Penninger, Wallace Y. Langdon, Jian Zhang
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001210

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http://www.sciencedirect.com/science/article/pii/S2211124712001210

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