Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) to a genetically-engineered murine m...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2024-01-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-024-44776-4

Rhyngrwyd

https://doi.org/10.1038/s41467-024-44776-4

Eitemau Tebyg