MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

Abstract Mammalian Müller glia (MG) possess limited regenerative capacities. However, the intrinsic capacity of mammalian MG to transdifferentiate to generate mature neurons without transgenic manipulations remains speculative. Here we show that MAP4K4, MAP4K6 and MAP4K7, which are conserved Misshap...

Full description

Bibliographic Details
Main Authors: Houjian Zhang, Yuli Guo, Yaqiong Yang, Yuqian Wang, Youwen Zhang, Jingbin Zhuang, Yuting Zhang, Mei Shen, Jiankai Zhao, Rongrong Zhang, Yan Qiu, Shiying Li, Jiaoyue Hu, Wei Li, Jianfeng Wu, Haiwei Xu, Steven J. Fliesler, Yi Liao, Zuguo Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00310-6

Internet

https://doi.org/10.1038/s41536-023-00310-6

Similar Items