Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus

Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus

Dnmt3a2, a <i>de novo</i> DNA methyltransferase, is induced by neuronal activity and participates in long-term memory formation with the increased expression of synaptic plasticity genes. We wanted to determine if Dnmt3a2 with its partner Dnmt3L may influence motor behavior via the dopam...

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Bibliographic Details
Main Authors: Di Cui, Andrea Mesaros, Gregor Burdeos, Ingo Voigt, Patrick Giavalisco, Yvonne Hinze, Martin Purrio, Bernd Neumaier, Alexander Drzezga, Yayoi Obata, Heike Endepols, Xiangru Xu
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
DNA methylation
transgenic mouse model
behavioral paradigms
positron emission tomography
dopaminergic system
Online Access:https://www.mdpi.com/1422-0067/21/17/6297

Internet

https://www.mdpi.com/1422-0067/21/17/6297

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