Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Abstract Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, macrophages in mechanosensitive tissues receive mechanical signals that regulate vari...

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Bibliographic Details
Main Authors: Kentaro Maruyama, Eiji Nemoto, Satoru Yamada
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Inflammation and Regeneration
Subjects:
Mechanical stress
Cyclic stretch
Inflammasome
Macrophage
Online Access:http://link.springer.com/article/10.1186/s41232-019-0092-2

Internet

http://link.springer.com/article/10.1186/s41232-019-0092-2

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