Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity

Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity

BackgroundThe healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood. Phosphofructokinase 2 (PFK‐2) is a primary regulator o...

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Bibliographic Details
Main Authors: Lee B. Bockus, Satoshi Matsuzaki, Shraddha S. Vadvalkar, Zachary T. Young, Jennifer R. Giorgione, Maria F. Newhardt, Michael Kinter, Kenneth M. Humphries
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
autophagy
diabetic cardiomyopathy
glycolysis
insulin action
insulin resistance
metabolism
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007159

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.007159

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