Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson–Gilford Progeria Syndrome

Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford Progeria Syndrome (HGPS) is an ultra-rare human premature aging disorder that precipitates death because of cardiac disease. Almost all cases of HGPS are caused by aberrant splicing of the <i>LMNA</i> gene that results in the production of a mutant Lamin A protein term...

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Bibliographic Details
Main Authors: So-mi Kang, Seungwoon Seo, Eun Ju Song, Okhee Kweon, Ah-hyeon Jo, Soyoung Park, Tae-Gyun Woo, Bae-Hoon Kim, Goo Taeg Oh, Bum-Joon Park
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
Hutchinson–Gilford Progeria Syndrome (HGPS)
progerin
cardiac dysfunction
fibrosis
<i>Lmna<sup>G609G</sup></i> model mouse
Progerinin
Online Access:https://www.mdpi.com/2073-4409/12/9/1232

Internet

https://www.mdpi.com/2073-4409/12/9/1232

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