Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

<p>Abstract</p> <p>Background</p> <p>Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for...

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Bibliographic Details
Main Authors: Yang Jia-Le, Xu Bo, Li Shuang-Shuang, Zhang Wei-Shi, Xu Hua, Deng Xiao-Ming, Zhang Yu-Qiu
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Molecular Brain
Subjects:
α2/δ-1 subunit of Voltage-gated calcium channels
CX3CL1
CX3CR1
Gabapentin
Glial activation
Monoarthritis
Online Access:http://www.molecularbrain.com/content/5/1/18

Internet

http://www.molecularbrain.com/content/5/1/18

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