Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig

Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig

One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) microparticles to attenuate allograft rejection. CsA-elutin...

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Bibliographic Details
Main Authors: Purushothaman Kuppan, Jordan Wong, Sandra Kelly, Jiaxin Lin, Jessica Worton, Chelsea Castro, Joy Paramor, Karen Seeberger, Nerea Cuesta-Gomez, Colin C. Anderson, Gregory S. Korbutt, Andrew R. Pepper
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
type 1 diabetes
localized drug delivery
cyclosporine A
murine islet allograft
islet transplantation
CTLA4-Ig
Online Access:https://www.mdpi.com/1999-4923/15/9/2201

Internet

https://www.mdpi.com/1999-4923/15/9/2201

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