METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

Abstract Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is still unknown. Methods Neonatal rat cardiomyocytes (NRCMs) and C57BL/6...

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Bibliographic Details
Main Authors: Rui Zhang, Yangyang Qu, Zhenjun Ji, Chunshu Hao, Yamin Su, Yuyu Yao, Wenjie Zuo, Xi Chen, Mingming Yang, Genshan Ma
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Cardiac hypertrophy
Angiotensin II
METTL3
miR-221/222
Wnt/β-catenin signaling
Online Access:https://doi.org/10.1186/s11658-022-00349-1

Internet

https://doi.org/10.1186/s11658-022-00349-1

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